Advances in the Genetics and Biology of Pancreatic Cancer.
Cancer J. 2017 Nov/Dec;23(6):315-320. doi: 10.1097/PPO.0000000000000286. Aguirre AJ, Collisson EA.
Pancreatic ductal adenocarcinoma (PDA) remains one of the most devastating diagnoses in modern medicine. While the clinical management of the disease has improved, the complex biologic underpinnings of PDA enable both its aggressive nature and slow clinical translational progress. In this review, we provide an overview of the key features of PDA genetics and biology, highlighting translational challenges and providing a framework for improved diagnostic and therapeutic approaches.